Usually, a woman with any of the conditions listed below should not use monthly injectables. In special circumstances, however, when other, more appropriate methods are not available or acceptable to her, a qualified provider who can carefully assess a specific woman’s condition and situation may decide that she can use monthly injectables. The provider needs to consider the severity of her condition and, for most conditions, whether she will have access to follow-up.

• Not breastfeeding and less than 3 weeks since giving birth, without additional risk that she might develop a blood clot in a deep vein (VTE)
• Not breastfeeding and between 3 and 6 weeks postpartum with additional risk that she might develop VTE
• Primarily breastfeeding between 6 weeks and 6 months since giving birth
• Age 35 or older and smokes more than 15 cigarettes a day
• High blood pressure (systolic blood pressure between 140 and 159 mm Hg or diastolic blood pressure between 90 and 99 mm Hg)
• Controlled high blood pressure, where continuing evaluation is possible
• History of high blood pressure, where blood pressure cannot be taken (including pregnancy-related high blood pressure)
• Severe liver disease, infection, or tumor
• Age 35 or older and has migraine headaches without aura
• Younger than age 35 and has migraine headaches that have developed or have gotten worse while using monthly injectables
• Had breast cancer more than 5 years ago, and it has not returned
• Diabetes for more than 20 years or damage to arteries, vision, kidneys, or nervous system caused by diabetes
• Multiple risk factors for arterial cardiovascular disease, such as older age, smoking, diabetes, and high blood pressure
• Taking lamotrigine. Monthly injectables may reduce the effectiveness of lamotrigine.