Usually, a woman with any of the conditions listed below should not use POPs. In special circumstances, however, when other, more appropriate methods are not available or acceptable to her, a qualified provider who can carefully assess a specific woman’s condition and situation may decide that she can use POPs. The provider needs to consider the severity of her condition and, for most conditions, whether she will have access to follow-up.

• Acute blood clot in deep veins of legs or lungs
• Had breast cancer more than 5 years ago, and it has not returned
• Severe cirrhosis or severe liver tumor
• Systemic lupus erythematosus with positive (or unknown) antiphospholipid antibodies
• Taking barbiturates, carbamazepine, oxcarbazepine, phenytoin, primidone, topiramate, rifampicin, or rifabutin. A backup contraceptive method should also be used because these medications reduce the effectiveness of POPs.